F13.280 Sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced anxiety disorder

ICD-10-CM F13.280: Sedative, hypnotic or anxiolytic dependence with induced anxiety disorder

ICD-10-CM code F13.280 denotes sedative, hypnotic or anxiolytic dependence accompanied by a sedative, hypnotic or anxiolytic-induced anxiety disorder. Clinical literature indicates that sedative and anxiolytic medications can produce physiological dependence. The available public sources establish the code's official description and related clinical context, though specific documentation guidelines are not detailed. 5 6 4

Plain-language overview

Sedative, hypnotic or anxiolytic use disorders are defined by significant impairment or distress caused by recurrent use of these substances. A subset of individuals who misuse these substances develop a sedative, hypnotic or anxiolytic use disorder. 2

What this code represents

The ICD-10-CM code F13.280 specifically represents sedative, hypnotic or anxiolytic dependence with sedative, hypnotic or anxiolytic-induced anxiety disorder. This code is listed under the broader F13.28 category for sedative, hypnotic or anxiolytic dependence. 5 6

Clinical context

Benzodiazepines cause gamma-aminobutyric acid receptor downregulation within weeks of use, and tolerance to their anxiolytic and hypnotic effects can develop soon after, accompanied by physiologic and psychological dependence. 4

The Diagnostic and Statistical Manual of Mental Disorders, 5th ed., text revision categorizes benzodiazepine use disorder as a subtype of the broader category of sedative, hypnotic, or anxiolytic use disorder. 4

Anxiolytics and sedative-hypnotic medications are used in clinical practice for managing central nervous system conditions, including anxiety disorders, insomnia, and seizure disorders. Anxiolytic and sedative-hypnotic toxicity is a significant cause of morbidity and mortality. 1

Documentation considerations

A CMS billing and coding article for urine drug testing includes F13.19, the code for sedative, hypnotic or anxiolytic abuse with unspecified induced disorder, in a list of anxiolytic-induced disorder diagnosis codes. 3

What the sources add

Clinical reference sources describe the physiological mechanisms of dependence and the formal diagnostic categorization of these use disorders, whereas coding references provide the specific ICD-10-CM code descriptions for the F13.28 category. 4 5

Clinical literature notes that the prevalence of anxiolytic and sedative use disorder is estimated at approximately 0.16% of the general population, while diagnosed sedative, hypnotic or anxiolytic use disorders increased 3- to 5-fold among adolescent and young adult Medicaid enrollees between 2001 and 2019. 1 2

Sources

1. Bookshelf — ncbi.nlm.nih.gov; accessed 2026-07-25.
2. Nationwide trends in diagnosed sedative, hypnotic or anxiolytic use disorders in adolescents and young adults enrolled in Medicaid: 2001–2019 — pmc.ncbi.nlm.nih.gov; accessed 2026-07-25.
3. Article - Billing and Coding: Urine Drug Testing (A56818) — cms.gov; accessed 2026-07-25.
4. Benzodiazepine Use Disorder: Common Questions and Answers — aafp.org; accessed 2026-07-25.
5. F13.28 ICD-10-CM Code — Sedative, hypnotic or anxiolytic dependence… — simplepractice.com; accessed 2026-07-25.
6. F13.20 ICD-10-CM Code — Sedative, hypnotic or anxiolytic dependence… — simplepractice.com; accessed 2026-07-25.