C82.58 Diffuse follicle center lymphoma, lymph nodes of multiple sites

ICD-10-CM Diagnosis Code C82.58: Diffuse Follicle Center Lymphoma, Lymph Nodes of Multiple Sites

ICD-10-CM code C82.58 identifies diffuse follicle center lymphoma located in the lymph nodes of multiple anatomical sites. This active diagnosis concept is classified as a neoplastic process and is a specific, narrower subset of the parent category for diffuse follicle center lymphoma. It is distinct from other site-specific lymphoma codes. 1 2

Plain-language overview

Lymphoma is a cancer of the lymph system, originating when white blood cells called T cells or B cells become abnormal, which provides general clinical context for this diagnosis category. 6

The official terminology record assigns C82.58 the semantic type of neoplastic process and gives it a preferred name specifying diffuse follicle center lymphoma across multiple lymph node sites. 1

What this code represents

Code C82.58 represents a specific, narrower diagnostic concept under the parent code C82.5 for diffuse follicle center lymphoma, specifically indicating involvement of multiple lymph node sites. 1

This diagnosis code is distinct from diffuse follicle center lymphoma affecting single regions like the head, face, neck, thoracic, abdominal, pelvic, axillary, or inguinal lymph nodes. 2

Coding details

The terminology record for C82.58 is active for the 2026 version of ICD-10-CM and includes the published abbreviation for lymph nodes in multiple sites. 1

Code C82.58 is listed alongside other specific site variations, distinguishing multiple site involvement from extranodal and solid organ sites designated by code C82.59. 2

Documentation considerations

The official terminology record for C82.58 specifies the diagnosis as diffuse follicle center lymphoma in the lymph nodes of multiple sites, establishing the exact clinical language for this concept. 1

What the sources add

The official terminology authority defines the clinical meaning and hierarchy of C82.58, while a state Medicaid billing guideline explicitly lists the code alongside other site-specific lymphoma variations. 1 2

A university cancer research mapping resource includes the exact preferred name for C82.58, while a state Medicaid billing guideline lists the code among other diffuse follicle center lymphoma site variations. 2 3

Sources

1. ICD-10-CM C82.58 terminology record — National Cancer Institute Enterprise Vocabulary Services; accessed 2026-07-27.
2. Bendamustine Hydrochloride Injection, for Intravenous Use (Baxter) HCPCS Code J9999 - Not Otherwise Classified, Antineoplastic: Billing Guidelines — medicaid.ncdhhs.gov; accessed 2026-07-27.
3. Phecode 202 · Cancer PRSweb — csg.sph.umich.edu; accessed 2026-07-27.
4. Article - Billing and Coding: Allogeneic Hematopoietic Cell Transplantation for Primary Refractory or Relapsed Hodgkin's and Non-Hodgkin's Lymphoma with B-cell or T-cell Origin (A59175) — cms.gov; accessed 2026-07-27.
5. Article - Billing and Coding: MolDX: Minimal Residual Disease Testing for Hematologic Cancers (A58996) — cms.gov; accessed 2026-07-27.
6. C82.51 — Diffuse follicle center lymphoma, lymph nodes of head, face, and neck | ICD-10 Code · Eleplan — eleplan.com; accessed 2026-07-27.