C81.28 Mixed cellularity Hodgkin lymphoma, lymph nodes of multiple sites

ICD10CM code

#### Name of the Condition
- Mixed Cellularity Hodgkin Lymphoma of Lymph Nodes of Multiple Sites (ICD-10: C81.28)

#### Summary
Mixed Cellularity Hodgkin Lymphoma is a type of Hodgkin lymphoma characterized by a diverse mix of cell types found within the affected lymph nodes across multiple areas of the body. It is one of the subtypes of Hodgkin lymphoma, a cancer that originates in the lymphatic system.

#### Causes
The exact cause of Mixed Cellularity Hodgkin Lymphoma is not well understood, but it may have links to genetic mutations, immune system deficiencies, and prior infections with Epstein-Barr virus (EBV).

#### Risk Factors
- Age: Most common in middle-aged individuals.
- Gender: Slightly more prevalent in males than females.
- Family history of lymphoma or other hematological cancers.
- Past infection with Epstein-Barr virus.

#### Symptoms
- Swollen lymph nodes, usually painless.
- Fever and night sweats.
- Unexplained weight loss.
- Fatigue and weakness.
- Itching of the skin.

#### Diagnosis
- Physical examination and medical history review.
- Imaging tests such as CT, PET, or MRI scans to identify affected areas.
- Lymph node biopsy to assess cellular composition.
- Blood tests to evaluate overall health and organ function.

#### Treatment Options
- Chemotherapy: Utilized to kill cancer cells or stop their growth.
- Radiation therapy: Targets and destroys cancerous cells in specific areas.
- Immunotherapy: Boosts the body's immune system to fight cancer.
- Stem cell transplant: May be considered in advanced cases to replace diseased bone marrow.

#### Prognosis and Follow-Up
The prognosis for patients with Mixed Cellularity Hodgkin Lymphoma is generally good, with high treatment success rates. Regular check-ups and monitoring are crucial to detect any recurrence early and manage long-term health.

#### Complications
If left untreated, the lymphoma can spread to other organs, leading to compromised immune function and severe health issues.

#### Lifestyle & Prevention
- Regular medical check-ups for those at risk.
- Maintaining a healthy lifestyle with a balanced diet and regular exercise can bolster immune health.
- Avoidance of known risk factors, like smoking or exposure to carcinogens, may reduce risk.

#### When to Seek Professional Help
Consult a healthcare provider if you experience persistent swollen lymph nodes, fever, weight loss, night sweats, or fatigue without a clear cause.

#### Additional Resources
- Leukemia & Lymphoma Society ([www.lls.org](https://www.lls.org))
- American Cancer Society ([www.cancer.org](https://www.cancer.org))
- Lymphoma Research Foundation ([www.lymphoma.org](https://www.lymphoma.org))

#### Tips for Medical Coders
- Ensure the correct subtype of Hodgkin lymphoma is identified for accurate coding.
- Confirm the documentation clearly specifies it's affecting multiple lymph node sites to use ICD-10 code C81.28 appropriately.
- Double-check for any additional codes that may be needed for related symptoms or treatments.

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