Name of the Procedure:

Ustekinumab Intravenous Injection
Common Name: Stelara IV
Medical Term: Ustekinumab, for intravenous injection, 1 mg (Q9989)

Summary

Ustekinumab is a medication administered via intravenous injection that helps manage certain inflammatory conditions in the body. It's primarily used to treat disorders that involve the immune system attacking its own tissues or organs.

Purpose

Ustekinumab is designed to treat autoimmune and inflammatory conditions such as Crohn's disease, ulcerative colitis, and plaque psoriasis. The goal is to reduce inflammation, alleviate symptoms, and achieve long-term remission of these conditions.

Indications

• Moderate to severe Crohn's disease or ulcerative colitis in adults.
• Moderate to severe plaque psoriasis in adults.
• Patients who have not responded adequately to conventional therapies or have experienced intolerable side effects from these therapies.
• Specific patient criteria typically include a history of these conditions, documented by a healthcare provider.

Preparation

• Patients may need to fast for a few hours prior to the procedure.
• It’s important to inform the healthcare provider about any other medications being taken as well as any existing medical conditions.
• Pre-procedure blood tests or assessments may be required to ensure the patient is a good candidate for Ustekinumab therapy.

Procedure Description

1. A healthcare provider will insert an intravenous (IV) line into a vein, usually in the arm.
2. Ustekinumab is administered through the IV line over the course of about an hour.
3. The healthcare team monitors the patient for any immediate reactions during the infusion.
4. The patient is observed for a short period after the infusion to ensure there are no adverse reactions.

Duration

The infusion typically takes around one hour to complete.

Setting

The procedure is usually performed in a hospital or an outpatient clinic that is equipped to handle intravenous infusions.

Personnel

• A nurse or medical technician will administer the IV infusion.
• A physician will oversee the procedure and be available for consultation.
• In some cases, an anesthesiologist may be present if sedation is required.

Risks and Complications

• Common risks: mild infusion reactions such as headaches, nausea, or fatigue.
• Rare risks: serious allergic reactions, infections, or worsening of existing conditions.
• Management includes immediate medical intervention for any severe complications.

Benefits

• Reduction in symptoms such as pain, swelling, and skin lesions.
• Potential long-term remission of the inflammatory condition.
• Improvement in overall quality of life, often noticeable within a few weeks of the initial treatment.

Recovery

• Patients can typically resume normal activities shortly after the infusion.
• Post-procedure instructions may include monitoring for any delayed reactions.
• Follow-up appointments are crucial to assess treatment efficacy and adjust dosages if necessary.

Alternatives

• Other biologic treatments such as adalimumab or infliximab.
• Non-biologic systemic treatments like methotrexate or cyclosporine.
• Traditional medications including corticosteroids.
• Each alternative has its own benefits and risks; the choice depends on the specific condition and patient response to prior treatments.

Patient Experience

• During the procedure, the patient may feel a slight pinch when the IV is inserted.
• Some patients report a mild headache or fatigue after the infusion.
• Pain management strategies include over-the-counter pain relievers if needed.
• Comfort measures provided by the healthcare team can include a relaxed and supportive environment.