Name of the Procedure:

Injection, Temsirolimus, 1 mg (J9330)

• Common Name: Temsirolimus Injection
• Medical Term: Temsirolimus Intravenous Administration

Summary

Temsirolimus injection is a treatment typically used in managing certain types of cancer. It involves administering a solution containing 1 milligram of temsirolimus directly into the bloodstream through a vein (intravenously).

Purpose

Temsirolimus is primarily used in the treatment of renal cell carcinoma (kidney cancer). The main goal is to slow down or stop the growth of cancer cells.

Indications

• Advanced renal cell carcinoma
• Certain patients with relapsed multiple myeloma
• Conditions identified by an oncologist where temsirolimus may be beneficial

Preparation

• The patient may be advised to fast for a few hours before the procedure.
• Blood tests and imaging may be required beforehand to assess overall health and specific cancer characteristics.
• Patients should inform their healthcare team about all medications they are taking.

Procedure Description

1. The healthcare provider will clean an area on the patient's arm with an antiseptic solution.
2. An intravenous (IV) line will be inserted into a vein.
3. Temsirolimus solution will be prepared and administered slowly through the IV over a specific period.
4. The patient will be monitored during the infusion for any adverse reactions.

• Tools: IV line, antiseptic, temsirolimus solution, monitoring equipment.
• Anesthesia: Not typically required; local numbing for IV insertion may be used.

Duration

The entire procedure typically takes around 30 to 60 minutes, including preparation and monitoring.

Setting

• Performed in a hospital, outpatient oncology clinic, or an infusion center.

Personnel

• Oncologist
• Registered Nurse (RN)
• Medical Assistant (optional)

Risks and Complications

• Common: Mild pain at the injection site, nausea, fatigue.
• Rare: Severe allergic reactions, infections at the injection site, significant changes in blood cell counts.

Benefits

• Potential to slow or halt the progression of specific cancers.
• May lead to tumor shrinkage and improved survival times.
• Benefits may be seen in a few weeks to months, depending on individual response.

Recovery

• After the infusion, patients can generally return home the same day.
• Follow all post-procedure instructions given by the healthcare team.
• Minimal activity restrictions; some patients may need to rest and avoid strenuous activities for the remainder of the day.
• Regular follow-up appointments for monitoring and additional infusions as prescribed.

Alternatives

• Other chemotherapy agents
• Targeted therapy drugs (e.g., sunitinib, everolimus)
• Surgery or radiation, depending on cancer type and stage
• Pros and cons: Alternatives vary in effectiveness, side effects, and suitability depending on individual patient cases.

Patient Experience

• During the procedure: Patients might feel a mild discomfort from the IV insertion and some sensation of the infusion.
• After the procedure: Possible tiredness or mild nausea; pain management including over-the-counter pain relief may be advised.
• Comfort measures: Warm blankets, hydration, and a calm environment help improve comfort during and after the procedure.