Name of the Procedure:

Injection of copanlisib, 1 mg
Common Names: Copanlisib injection
Medical Term: J9057 - Injection, copanlisib, 1 mg

Summary

The injection of copanlisib is a medical procedure where 1 mg of copanlisib, a cancer medication, is administered intravenously to the patient. This drug targets and inhibits specific proteins within cancer cells, preventing their growth and proliferation.

Purpose

The injection of copanlisib is primarily used to treat adult patients with relapsed follicular lymphoma, a type of non-Hodgkin lymphoma. The goal of the procedure is to inhibit cancer cell growth, potentially shrinking tumors and slowing the progression of the disease.

Indications

Specific Symptoms or Conditions:

• Relapsed follicular lymphoma
• Inadequate response to at least two prior therapies

Patient Criteria:

• Adults diagnosed with follicular lymphoma
• Previous treatment regimens have been unsuccessful

Preparation

Pre-Procedure Instructions:

• No fasting typically required
• Adjustments to current medications may be necessary
• Inform the doctor of any known allergies or medical conditions

Diagnostic Tests or Assessments:

• Blood tests to check organ function
• Imaging studies such as CT or PET scans
• Physical examination and medical history review

Procedure Description

1. Initial Assessment: The healthcare provider conducts a preliminary evaluation.
2. IV Line Placement: An IV line is established, often in the arm, to deliver the medication.
3. Drug Preparation: Copanlisib is prepared according to the required dosage.
4. Administration: The drug is administered via the IV line over a period of approximately one hour.
5. Monitoring: Vital signs are closely monitored during and after the administration to observe any immediate reactions.

Tools, Equipment, or Technology:

• Sterile needles and catheters
• Infusion pump
• Monitoring equipment for vital signs

Anesthesia or Sedation: Not typically required, but pain management options are available if needed.

Duration

The procedure generally takes about 1.5 to 2 hours, including the preparation, administration of the drug, and post-procedure observation.

Setting

The procedure is usually performed in an outpatient clinic, hospital oncology department, or an infusion center.

Personnel

• Oncologist or hematologist
• Registered nurse
• Pharmacist (for drug preparation)
• Support staff (if necessary)

Risks and Complications

Common Risks:

• Fatigue
• Nausea
• Diarrhea
• Hyperglycemia (high blood sugar)
• Hypertension (high blood pressure)

Rare Risks:

• Severe allergic reactions
• Infections due to immune suppression
• Pneumonitis (lung inflammation)

Possible Complications: Immediate medical attention and supportive care are available to manage these complications.

Benefits

Expected Benefits:

• Reduction in tumor size
• Slowed disease progression
• Potential remission of cancer

Timeline for Benefits: Benefits can typically be observed after several cycles of treatment, which will be evaluated by the healthcare provider.

Recovery

Post-Procedure Care and Instructions:

• Hydration is important; patients are encouraged to drink fluids.
• Monitor for side effects and report any severe symptoms to the healthcare provider.

Expected Recovery Time:

• Recovery is generally immediate for the procedure itself, but ongoing monitoring for side effects is necessary.

Restrictions or Follow-Up Appointments:

• Keep all follow-up appointments for lab tests and assessments
• Avoid strenuous activities as advised by the doctor

Alternatives

Other Treatment Options:

• Other chemotherapy drugs
• Immunotherapy
• Radiation therapy
• Stem cell transplant

Pros and Cons:

• Alternatives may offer different efficacy, side effect profiles, and suitability depending on the patient’s medical history and condition.

Patient Experience

During the Procedure:

• Mild discomfort from IV insertion
• Minimal to no pain during the infusion itself
• Some patients may feel fatigued or slightly nauseous

After the Procedure:

• Possible fatigue, requiring rest
• Management of side effects may include medications and supportive care measures provided by the healthcare team to ensure comfort and well-being.

Pain management and comfort measures are tailored to each individual patient to minimize discomfort and enhance the overall experience.