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Injection, luspatercept-aamt, 0.25 mg

HCPCS code

Name of the Procedure:

Injection, Luspatercept-aamt, 0.25 mg (HCPCS Code: J0896)


An injection of Luspatercept-aamt is a medical procedure for administering a medication aimed at treating specific blood disorders. It involves delivering a precise dose of 0.25 mg of the drug via subcutaneous injection, meaning the medication is injected just under the skin.


Luspatercept-aamt is used to treat anemia in adults with beta thalassemia who require regular red blood cell transfusions. It aims to reduce the dependence on these transfusions by helping the body to produce more red blood cells naturally.


  • Severe anemia in adults with beta thalassemia
  • Regular requirement of red blood cell transfusions
  • Ineffectiveness or contraindication of other conventional treatments


  • Patients may need to undergo a complete blood count (CBC) and possibly other blood tests to assess baseline health.
  • Inform your healthcare provider about any medications or supplements you are currently taking.
  • Fasting is generally not required, but follow specific instructions given by your healthcare provider.

Procedure Description

  1. Preparation: The injection site is cleaned with an antiseptic.
  2. Administration: Using a fine needle, the healthcare provider injects 0.25 mg of Luspatercept-aamt just under the skin, usually at a pre-selected site like the upper arm, thigh, or abdomen.
  3. Post-injection: The site is then monitored for a few minutes for any immediate reactions.

Tools/Technology Used: Syringe and fine needle, antiseptic wipes, possibly a bandage.

Anesthesia/Sedation: Not typically required, though topical numbing cream may be used if the patient has concerns about discomfort.


The injection procedure itself takes only a few minutes.


This procedure can be performed in various healthcare settings, including:

  • Hospital
  • Outpatient clinic
  • Doctor’s office


  • Licensed healthcare providers such as nurses or physicians typically administer the injection.
  • A pharmacist may be involved in preparing the medication dose.

Risks and Complications

  • Common: Site pain, redness, or swelling; minor bleeding at the injection site.
  • Rare: Allergic reactions, injection site infection, fatigue or headache.
  • Management: Keep the site clean, use over-the-counter pain relievers as recommended, contact healthcare provider if severe reactions occur.


  • Decreased need for regular red blood cell transfusions.
  • Improved quality of life by reducing the symptoms of anemia.
  • Benefits can often be seen within a few weeks of regular treatment.


  • Minimal downtime; patients can typically resume normal activities immediately.
  • Follow-up appointments will be scheduled to monitor the effectiveness and make any dosage adjustments.
  • Keep track of any side effects and report them to your healthcare provider.


  • Continuing regular red blood cell transfusions.
  • Erythropoiesis-stimulating agents.
  • Bone marrow transplant (more invasive with its own set of risks and benefits).

Pros: Non-invasive, potentially reduces need for transfusions. Cons: Regular injections, potential side effects, ongoing follow-up required.

Patient Experience

  • During: Slight discomfort at the injection site.
  • After: Monitor for any immediate side effects like redness or swelling. Pain management can include over-the-counter pain relievers as needed.
  • Overall: The procedure is quick, with minimal discomfort and a short recovery period, allowing most patients to resume their regular activities almost immediately.

Medical Policies and Guidelines for Injection, luspatercept-aamt, 0.25 mg

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