Injection, patisiran, 0.1 mg
HCPCS code
Name of the Procedure:
Common Name: Injection of patisiran
Technical/Medical Term: Injection, patisiran, 0.1 mg (HCPCS Code: C9036)
Summary
Patisiran injections are used to treat a specific type of nerve damage caused by hereditary transthyretin-mediated amyloidosis (hATTR). This injectable therapy delivers the medication directly into the body to help alleviate symptoms and slow disease progression.
Purpose
Patisiran is designed to treat hereditary transthyretin-mediated amyloidosis (hATTR), a condition where abnormal protein deposits cause nerve damage. The goal is to reduce these deposits, alleviate symptoms, and improve the quality of life for patients.
Indications
Patisiran is indicated for patients diagnosed with hATTR who exhibit symptoms such as pain, numbness, or weakness due to nerve damage. It is specifically for those with confirmed genetic mutations and clinical manifestations of hATTR.
Preparation
Patients usually don't need special preparation for patisiran injections. However, the doctor may recommend some routine blood tests and check up on your overall health status. It's crucial to inform your healthcare provider about any current medications or underlying health conditions.
Procedure Description
- Initial Consultation: Explain the benefits and risks of the procedure.
- Pre-Injection Checks: Routine blood tests and assessments.
- Administration: The nurse or doctor will inject patisiran directly into a vein through an IV line.
- Observation: Post-injection monitoring for any immediate side effects.
No anesthesia or sedation is typically required, and the procedure is minimally invasive.
Duration
The injection process itself takes about 80 minutes, including preparation and monitoring time.
Setting
This procedure is commonly performed in an outpatient clinic, hospital infusion center, or specialized treatment centers.
Personnel
- Primary Care Physician / Neurologist
- Oncology/Hematology Nurse
- Pharmacist, if specialized handling of medication is required
Risks and Complications
Common risks may include:
- Injection Site Reactions: Redness, swelling, or discomfort.
- Allergic Reactions: Rare but serious reactions such as rash, itching, or difficulty breathing.
- Other Side Effects: Fatigue, headache, or flu-like symptoms.
Benefits
The primary benefit of patisiran injections is the reduction in symptoms and slowing the progression of hATTR. Patients may start to notice improvements in their symptoms within several weeks to months of regular treatment.
Recovery
No significant recovery time is required. Patients can usually resume normal activities immediately after the injection, although rest is advised if they experience fatigue or minor side effects. Regular follow-up appointments are necessary to monitor treatment efficacy and patient health.
Alternatives
Other treatment options for hATTR include:
- Tafamidis (Vyndaqel): An oral medication.
- Liver Transplant: For certain eligible patients.
Each option has its pros and cons, such as varying efficacy, side effects, cost, and availability, which should be discussed with your healthcare provider.
Patient Experience
During the procedure, the patient might feel a slight prick at the injection site and a cool sensation as the medication enters the bloodstream. Post-procedure, patients may feel fatigue or mild discomfort but can usually manage these with simple pain relief measures and rest.
By following the medical guidance and keeping up with follow-up appointments, patients can maximize the benefits of patisiran injections and effectively manage their condition.