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Anticoagulant management for an outpatient taking warfarin, physician review and interpretation of International Normalized Ratio (INR) testing, patient instructions, dosage adjustment (as needed), and ordering of additional tests; initial 90 days of ther

CPT4 code

Name of the Procedure:

Anticoagulant Management for Warfarin Therapy
Common name(s): Warfarin Management, INR Monitoring


This procedure involves the management of warfarin therapy in outpatients. It includes physician review and interpretation of International Normalized Ratio (INR) testing, providing patient instructions and adjusting the warfarin dosage as needed, and ordering any additional necessary tests. This guidance spans the initial 90 days of treatment.


Medical Condition or Problem:
  • Thromboembolic disorders
  • Atrial fibrillation
  • Deep vein thrombosis (DVT)
  • Pulmonary embolism (PE)
  • Mechanical heart valve maintenance
  • Maintain a therapeutic INR range
  • Prevent blood clots
  • Reduce risk of bleeding
  • Optimize patient safety and medication efficacy


  • Patients diagnosed with conditions requiring anticoagulation
  • Presence of atrial fibrillation, DVT, PE, mechanical heart valves
  • New initiation of warfarin therapy


  • No specific fasting or preparation required.
  • Regular INR blood tests should be scheduled.
  • Obtain a comprehensive patient history, including current medications and diet.

Procedure Description

  1. Review and Interpretation of INR: The physician reviews recent INR test results to determine if the patient's warfarin dosage is within the therapeutic range.
  2. Patient Instructions: The patient is educated on warfarin management, dietary considerations, and signs of complications.
  3. Dosage Adjustment: Based on INR results, the physician adjusts the warfarin dosage if necessary.
  4. Ordering Additional Tests: Extra diagnostic tests may be requested if the INR levels are unstable or if there are suspected complications.
  • INR testing equipment
  • Patient education materials
Anesthesia or Sedation:
  • Not applicable


  • Initial consultation: 15-30 minutes
  • Follow-up reviews: 10-15 minutes


  • Outpatient clinic
  • Physician's office


  • Physician (general practitioner, cardiologist, or hematologist)
  • Nurse or medical assistant

Risks and Complications

  • Common Risks: Minor bleeding, dietary restrictions affecting INR levels.
  • Rare Complications: Severe bleeding (gastrointestinal, intracranial), interactions with other medications.


  • Effective prevention of thromboembolic events
  • Improved patient understanding and self-management
  • Enhanced safety and precise control of anticoagulant effect


  • No specific recovery as this is a management plan involving regular monitoring.
  • Continuous adjustment based on routine INR results.
  • Follow-up appointments based on physician’s discretion or if complications arise.


  • Direct oral anticoagulants (DOACs) like rivaroxaban, apixaban, dabigatran
  • Pros: Less frequent monitoring, fewer dietary restrictions
  • Cons: Lack of reversal agents for some DOACs, cost

Patient Experience

  • Regular blood draws for INR testing
  • Ongoing communication with healthcare providers to adjust dosage and manage side effects
  • Patient education to understand diet, medication interactions, and signs of complications
  • Generally well-tolerated with proper monitoring and management

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