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Antinuclear antibodies (ANA); titer

CPT4 code

Name of the Procedure:

Antinuclear Antibodies (ANA) Test; ANA Titer


An Antinuclear Antibodies (ANA) test detects autoantibodies that target the nucleus of cells. These antibodies are often present in autoimmune disorders. The ANA titer measures the concentration of these antibodies in the blood, helping to diagnose and monitor autoimmune conditions.


The ANA test is used to diagnose autoimmune disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis, and scleroderma. The test helps in identifying these conditions early, facilitating timely and appropriate treatment.


  • Unexplained fatigue or fever
  • Persistent joint or muscle pain and swelling
  • Rashes, particularly a butterfly-shaped rash across the cheeks and nose
  • Symptoms suggestive of an autoimmune disorder


  • No specific fasting or diet restrictions are needed.
  • Patients should inform their healthcare provider about any medications they are taking, as some drugs can interfere with the test results.

Procedure Description

  1. A healthcare professional will draw a blood sample from a vein in your arm.
  2. The sample is sent to a laboratory for analysis.
  3. The lab uses specific techniques to identify the presence and concentration (titer) of antinuclear antibodies.


The blood draw itself takes about 5-10 minutes. Laboratory results are typically available within a few days to a week.


The procedure is usually performed in an outpatient clinic, hospital, or laboratory.


  • Phlebotomist or nurse to draw the blood
  • Laboratory technologists to analyze the sample
  • Physician or specialist to interpret the results

Risks and Complications

  • Minor bruising or bleeding at the needle site
  • Rarely, infection at the puncture site


  • Identifies the presence of autoantibodies, aiding in the diagnosis of autoimmune diseases.
  • Helps monitor disease progression and effectiveness of treatment.
  • Results are generally available within a week.


  • Minimal to no recovery time needed.
  • Patients can resume normal activities immediately after the blood draw.
  • Follow-up with a healthcare provider may be needed to discuss results and plan further care if necessary.


  • Specific antibody tests targeting particular autoimmune diseases (e.g., Anti-dsDNA for lupus).
  • Imaging studies or biopsies may also be used for diagnosis.


  • More specific tests can provide additional information for a precise diagnosis.


  • Might not be comprehensive for all potential autoimmune disorders.

Patient Experience

  • Slight sting or pinch when the needle is inserted.
  • Minor discomfort or bruising afterwards.
  • Generally low pain and quick, simple procedure.

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