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Autoimmune (rheumatoid arthritis), analysis of 12 biomarkers using immunoassays, utilizing serum, prognostic algorithm reported as a disease activity score

CPT4 code

Name of the Procedure:

Autoimmune (rheumatoid arthritis), analysis of 12 biomarkers using immunoassays, utilizing serum, prognostic algorithm reported as a disease activity score. Common name(s): Rheumatoid arthritis biomarker panel, RA biomarker analysis.


This procedure involves analyzing a blood sample to measure levels of 12 specific biomarkers associated with rheumatoid arthritis. The results are used to generate a score that helps doctors predict the severity and progression of the disease.


The primary purpose of this procedure is to help manage rheumatoid arthritis by providing detailed insights into disease activity. It helps doctors customize treatment plans and monitor response to therapy.


  • Persistent joint pain and swelling.
  • Morning stiffness lasting longer than 30 minutes.
  • Positive rheumatoid factor or anti-CCP antibody test.
  • Patients diagnosed with rheumatoid arthritis who need ongoing disease activity monitoring.


  • Patients may be instructed to fast for a few hours before the blood draw.
  • Some medications may need to be paused prior to the test, as per doctor’s advice.
  • Recent medical history and current symptoms should be discussed with the healthcare provider.

Procedure Description

  1. A blood sample is collected from the patient, typically from a vein in the arm.
  2. The sample is processed and analyzed using immunoassays to measure 12 specific biomarkers.
  3. The biomarker levels are input into a prognostic algorithm.
  4. The algorithm calculates a disease activity score, which is reported to the doctor.


  • Standard blood collection equipment (needles, syringes, vials).
  • Immunoassay laboratory kits and machines.


  • Generally not required; only local discomfort from blood draw.


The blood draw itself takes about 10 minutes. The analysis and reporting might take a few days.


This procedure can be performed in an outpatient clinic, a hospital laboratory, or a specialized diagnostic center.


  • Phlebotomist or nurse for blood collection.
  • Laboratory technician or specialist for sample analysis.
  • Rheumatologist or primary care doctor for interpreting the results.

Risks and Complications

  • Minor: Bruising, slight pain at the needle site, fainting.
  • Rare: Infection at the needle site.
  • Management: Applying pressure and a bandage post-draw, keeping the area clean.


  • Helps in early detection and precise monitoring of rheumatoid arthritis.
  • Enables personalized treatment plans.
  • Better prognostic insights for disease management.


  • Minimal recovery time; most patients can resume normal activities immediately.
  • Keep the needle site clean and dry for a few hours.
  • Follow-up appointment may be scheduled to discuss results and treatment adjustments.


  • Clinical assessment and traditional blood tests (e.g., ESR, CRP).
  • Imaging studies (e.g., X-rays, MRI).
  • Pros: Non-invasive nature.
  • Cons: May not provide as detailed a prognostic score as the biomarker panel.

Patient Experience

  • During: Minor discomfort during blood draw.
  • After: Usually no pain, but potential mild soreness at the needle site.
  • Pain management: Over-the-counter pain relievers if needed, though typically unnecessary.

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