80331 Analgesics, non-opioid; 6 or more

CPT4 Code 80331: Analgesics, non-opioid; 6 or more

CPT4 code 80331 is identified in public sources as pertaining to non-opioid analgesics. The provided excerpts list this code within outpatient excluded service documents and payer drug testing policies. These sources establish the code's label and its placement within specific coding lists, but do not define clinical parameters or guarantee coverage. 1 3 4

Plain-language overview

Public sources identify code 80331 by the label analgesics, non-opioid; 6 or more, placing it within a sequence of related codes for substance classes. 1 3

What this code represents

Code 80331 represents the concept of analgesics, non-opioid; 6 or more, and is listed sequentially before code 80332, which identifies antidepressants. 1 2

Coding details

In two source documents, code 80331 is listed immediately after a code for analgesics non-opioid 3-5 and immediately before code 80332 for antidepressants. 1 2

Documentation considerations

Payer policy documents include code 80331 within their drug testing frameworks, providing a specific numerical identifier for the listed non-opioid analgesic concept. 5 6

Coverage and utilization context

Code 80331 appears on an outpatient excluded services list for specific program years, identifying it within a formal enumeration of excluded service codes. 1 2

What the sources add

While one payer policy lists 80331 without a testing modifier, another source appends the term screening to the code's official label, adding a descriptive variation. 3 4

Multiple payer policy documents from different organizations include code 80331 within their drug testing specifications, showing its presence across separate payer lists. 3 5 6

Procedure and patient context

The provided excerpts label 80331 as analgesics, non-opioid; 6 or more, but the source texts do not describe the specific patient preparation or procedure steps for this code. 3 4

Questions to verify

The supplied excerpts do not establish the specific biological specimen type, the exact substances included, or the precise analytical methodology utilized for code 80331. 1 3

Sources

1. outpatient-cpt-hcpcs-excluded-services-list-py-2023-pace- ... — cms.gov; accessed 2026-07-27.
2. outpatient-cpt-hcpcs-excluded-services-list-py-2026-pace- ... — cms.gov; accessed 2026-07-27.
3. MEDICAL POLICY No. 91611-R4 — priorityhealth.com; accessed 2026-07-27.
4. Quantitative and Qualitative Drug Testing — mibluecrosscomplete.com; accessed 2026-07-27.
5. Payment Policy: Urine Specimen Validity Testing — es-es.wellcare.com; accessed 2026-07-27.
6. 674 Drug Testing in Pain Management and Substance Use ... — bluecrossma.com; accessed 2026-07-27.