Messenger RNA (mRNA) is the product of RNA transcription, the firsts step in protein synthesis. Testing for DNA in combination with mRNA has been proposed as a method of detecting, diagnosing and managing cancer; in particular, when DNA genetic testing identifies variants of uncertain significance.

Position Statement

Investigational and Not Medically Necessary:

Messenger RNA (mRNA) sequence analysis alone or in conjunction with DNA sequence analysis to aid in the classification of variations of uncertain significance or to otherwise detect, diagnose or manage cancer is considered investigational and not medically necessary.