Injection, Hydroxyprogesterone Caproate (Makena), 10 mg (Q9986)

Name of the Procedure:

• Common Name: Makena Injection
• Technical Term: Injection, Hydroxyprogesterone Caproate, 10 mg

Summary

The Makena injection is a progesterone hormone treatment administered through an injection to help reduce the risk of preterm birth in certain at-risk pregnant women.

Purpose

The primary purpose of Makena is to lower the chances of early delivery. It aims to prolong pregnancy and allow the baby more time to develop in the womb.

Indications

• History of spontaneous preterm birth in a previous pregnancy
• Singleton pregnancy (carrying one baby)
• Pregnancy between 16 and 37 weeks gestation

Preparation

• No specific fasting or dietary restrictions are required.
• The patient should inform the healthcare provider about any allergies or current medications.
• A thorough medical history and physical examination are conducted.

Procedure Description

1. Patient Positioning: The patient lies on their side or stands up.
2. Injection Site Preparation: The injection site, usually the upper outer quadrant of the buttock, is cleaned with an antiseptic.
3. Injection: A healthcare provider uses a syringe to inject 10 mg of Hydroxyprogesterone Caproate deep into the muscle.
4. Aftercare: The site is covered with a small bandage.

Duration

The injection process typically takes about 5-10 minutes.

Setting

The procedure is commonly performed in an outpatient clinic or a doctor's office.

Personnel

• Registered Nurse (RN) or Licensed Practical Nurse (LPN)
• Occasionally a physician or nurse practitioner

Risks and Complications

• Common: Pain, swelling, or bruising at the injection site.
• Rare: Allergic reactions, blood clots, or fluid retention. Any adverse effects should be reported to the healthcare provider immediately.

Benefits

The main benefit is the reduced risk of preterm birth, potentially leading to healthier outcomes for the baby. Benefits can typically be seen with regular use as prescribed by the healthcare provider.

Recovery

• Post-injection: Patients are usually monitored briefly for any immediate reactions.
• Home Care: No specific care is required aside from monitoring the injection site for signs of infection.
• Follow-up: Regular injections are given weekly, starting between 16 and 20 weeks of pregnancy and continuing through 37 weeks or until delivery.

Alternatives

• Vaginal progesterone supplements may be considered.
• Lifestyle modifications, such as reduced physical activity and stress management.
• Each alternative has its own efficacy, risks, and benefits that should be discussed with the healthcare provider.

Patient Experience

• During Procedure: Discomfort similar to a typical intramuscular injection.
• After Procedure: Some soreness at the injection site is common but usually mild.
• Pain Management: Over-the-counter pain relievers, like acetaminophen, can be used if recommended by the healthcare provider.

By following these guidelines, the use of Hydroxyprogesterone Caproate injections can help manage and reduce the risk of preterm birth, contributing to better pregnancy outcomes.