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Management of recipient hematopoietic progenitor cell donor search and cell acquisition

CPT4 code

Name of the Procedure:

Management of Recipient Hematopoietic Progenitor Cell Donor Search and Cell Acquisition
Common name(s): Stem Cell Donor Search and Collection, Hematopoietic Stem Cell Procurement

Summary

This procedure involves finding a suitable donor for hematopoietic progenitor cells (stem cells) and collecting those cells for transplantation. This is a key step in treatments for certain blood disorders and cancers.

Purpose

The primary goal is to identify and obtain healthy stem cells for transplant into a patient with conditions such as leukemia, lymphoma, or aplastic anemia. This helps restore the patient's ability to produce healthy blood cells.

Indications

  • Patients with blood cancers (leukemia, lymphoma)
  • Patients with severe anemia or other blood disorders
  • Patients needing stem cell replacement due to high-dose chemotherapy or radiation

Preparation

  • Patients may need to undergo blood tests and diagnostic imaging to assess overall health.
  • Pre-procedure consultations with a hematologist and transplant team.
  • Possible adjustments to current medications as advised by the healthcare provider.

Procedure Description

  1. Donor Search:
    • The process begins with finding a matching stem cell donor through a registry or among relatives.
  2. Donor Pre-screening:
    • Health assessment and compatibility testing, including HLA (human leukocyte antigen) matching.
  3. Cell Acquisition:
    • Peripheral Blood Stem Cell (PBSC) collection: Donors receive injections of growth factors to increase stem cells in the blood. Cells are then collected via apheresis.
    • Bone Marrow Harvest: Under anesthesia, stem cells are collected directly from the donor's bone marrow using a needle.

Duration

  • Donor search can take several weeks to months.
  • PBSC collection typically takes 4-5 hours on a single day.
  • Bone Marrow Harvest may take 1-2 hours of surgical time.

Setting

  • Donor search and initial consultations: outpatient clinic.
  • Cell acquisition: specialized medical centers or hospitals with apheresis units or operating rooms.

Personnel

  • Hematologists
  • Transplant coordinators
  • Nurses specialized in apheresis or surgical procedures
  • Anesthesiologists (for bone marrow harvest)

Risks and Complications

  • Donor risks: Fatigue, bone pain (for PBSC donation), and infection at the collection site.
  • Rare complications include reactions to anesthetics (for bone marrow harvest) and prolonged pain or bleeding.
  • Recipient risks: Graft-versus-host disease (GVHD), infections, or complications from the transplant.

Benefits

  • Potential cure or remission of blood cancers and disorders.
  • Restoration of normal blood cell production.
  • Reduced long-term dependency on transfusions and medications.

Recovery

  • Donors: Mild side effects typically resolve within a few days to weeks. Follow-up appointments to ensure recovery.
  • Patients: Hospitalization for several weeks post-transplant, with ongoing monitoring. Recovery can take several months, with restrictions on physical activities and close follow-up care.

Alternatives

  • Autologous stem cell transplant (using patient's own cells).
  • Supportive treatments without transplant (medications, blood transfusions).
  • Each alternative has varying success rates, risks, and potential benefits compared to donor stem cell transplantation.

Patient Experience

  • During the donor search and cell acquisition, the patient may experience anxiety and anticipation.
  • Post-transplant recovery involves close monitoring, potential side effects from conditioning therapy, and pain management.
  • Emotional support and counseling are available to help manage stress and expectations during the transplant journey.

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