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Respiratory pathogen, multiplex reverse transcription and multiplex amplified probe technique, multiple types or subtypes, 20 targets (adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus, coronavirus OC43, human metapneumovirus, influenza A, influ

CPT4 code

Name of the Procedure:

Respiratory Pathogen Panel (multiplex reverse transcription and multiplex amplified probe technique, multiple types or subtypes, 20 targets including adenovirus, coronavirus 229E, HKU1, OC43, human metapneumovirus, influenza A and others)


This procedure tests for multiple respiratory pathogens in a single sample using advanced molecular techniques. It detects the genetic material of 20 different viruses and bacteria that cause respiratory infections.


The primary purpose is to diagnose respiratory infections caused by a wide range of viruses and bacteria. This helps healthcare providers to:

  • Identify the specific pathogen causing the infection.
  • Provide targeted treatment.
  • Prevent the spread of infection.


This test is indicated for patients presenting with symptoms of respiratory infections, such as:

  • Fever
  • Cough
  • Shortness of breath
  • Sore throat
  • Nasal congestion Patients who are especially vulnerable, such as the elderly, immunocompromised, or those with chronic illnesses, may also be candidates.


  • No specific preparation is typically required.
  • Patients may need to provide a sample of their nasal or throat secretions.
  • Follow any specific instructions from the healthcare provider.

Procedure Description

  1. Sample Collection:
    • A swab is inserted into the nose or throat to collect secretions.
  2. Sample Processing:
    • The sample is sent to a laboratory where the genetic material of pathogens is extracted.
  3. Analysis:
    • Using multiplex reverse transcription and amplified probe techniques, the lab tests for the presence of specific viral or bacterial RNA/DNA.
  4. Results:
    • Pathogen identification is typically available within hours to a couple of days, depending on the lab.


The sample collection takes only a few minutes. Laboratory analysis can take from several hours to a couple of days.


This procedure is typically performed in:

  • Hospitals
  • Outpatient clinics
  • Specialized diagnostic laboratories


  • Trained healthcare providers (e.g., nurses, medical assistants) collect the sample.
  • Medical laboratory technologists and microbiologists analyze the sample in the lab.

Risks and Complications

  • Common: Mild discomfort or gagging during the throat or nasal swab.
  • Rare: Slight nosebleed or irritation at the swab site.


  • Timely Diagnosis: Rapid and accurate identification of the infectious agent.
  • Targeted Treatment: Enables appropriate medical treatment based on the specific pathogen.
  • Reduced Spread: Helps contain the infection by identifying contagious viruses and bacteria.


  • No recovery time is required as the procedure is non-invasive and quick.
  • Follow-up appointments may be scheduled to discuss results and treatment plans.


  • Traditional Culture: Can be used but takes longer for results.
  • Other Molecular Tests: Single-test methods are available but may not cover as many pathogens.
  • Empirical Treatment: Based on clinical judgment without specific pathogen identification.

Patient Experience

  • During Procedure: Brief discomfort or tickling sensation during swabbing.
  • After Procedure: Generally, no pain or discomfort post-procedure.
  • Pain Management: Not typically necessary given the minimal invasiveness of sample collection.

Feel free to use this information to understand how the respiratory pathogen panel works and what to expect if you or someone you care for needs this test.

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