Chronic heart failure (CHF)

Chronic heart failure (CHF) is a common yet complex clinical syndrome. It affects millions of people every year and can be a debilitating condition. CHF is a progressive disorder of the heart characterized by an inability of the heart to pump enough blood to meet the needs of the body. This results in symptoms such as shortness of breath, fatigue, and edema. Treatment of CHF is multifactorial and includes lifestyle modifications, pharmacologic interventions, and device therapy.

Fluid overload is a common problem in patients with NYHA Class II and III chronic heart failure and can lead to increased morbidity and mortality if not properly managed. Treatment of fluid overload in these patients involve a combination of non-pharmacological and pharmacological measures. Pharmacological measures include the use of Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), angiotensin receptor neprilysin inhibitor (ARNIs), loop diuretics, and thiazide diuretics. These medications can help reduce fluid overload and improve symptoms. In addition, aldosterone antagonists may also be used if other measures are inadequate.

1Furoscix (furosemide) is indicated for the treatment of congestion due to fluid overload in adult patients with New York Heart Association (NYHA) Class II and Class III chronic heart failure.

• Furoscix is not indicated for use in emergency situations or in patients with acute pulmonary edema.
• The product is supplied in a single-dose prefilled cartridge for subcutaneous infusion co-packaged with the On-body Infusor. Each single-use on-body infusor with a prefilled cartridge is designed to deliver 80 mg of Furoscix in 10 mL solution over 5-hours.

Definitions

Anuria

is a medical term used to describe a condition in which a person's kidneys stop producing urine, or produce very little urine. Specifically, anuria is defined as the production of less than 50 milliliters of urine per day in adults.

Ascites

is a medical condition in which fluid accumulates in the abdominal cavity, causing abdominal swelling and discomfort. Ascites can be a complication of a variety of underlying health problems, including liver disease, heart failure, and certain types of cancer.

Chronic heart failure (CHF)

is a medical condition in which the heart is unable to pump enough blood to meet the body's needs. It occurs when the heart muscle is weakened or damaged, resulting in decreased blood flow to the organs and tissues. CHF can be caused by a variety of factors, including coronary artery disease, hypertension, heart valve disease, and cardiomyopathy.

Cirrhosis

is a chronic liver disease that results from damage to liver cells and the formation of scar tissue in the liver. This can lead to a variety of symptoms and complications, including jaundice, fatigue, fluid retention, and an increased risk of liver cancer.

Diuretic

is a medication that promotes the excretion of excess water and salt from the body through the kidneys, thereby increasing urine output. Diuretics are commonly used to treat conditions such as high blood pressure, heart failure, and edema. Diuretics can be classified into several categories based on their mechanism of action, such as loop diuretics, thiazide diuretics, potassium-sparing diuretics, and osmotic diuretics.

Edema

refers to the swelling of the body's tissues, typically due to the accumulation of excess fluid. In the context of heart failure, edema often occurs in the legs, ankles, and feet, but it can also affect the abdomen, lungs, and other parts of the body. Edema is caused by an imbalance in the body's fluid levels, which can result from the heart's inability to pump blood effectively.

Parenteral

is a term used to describe medications or nutrients that are delivered into the body through non-oral routes, such as injection or infusion.

This is in contrast to enteral administration, which involves delivering medications or nutrients through the digestive system, such as by mouth or through a feeding tube.

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