Anthem Blue Cross Connecticut Commercial Clinical Policy

Anthem Blue Cross Connecticut GENE.00018 Gene Expression Profiling for Cancers of Unknown Primary Site Form

Effective Date

09/27/2023

Last Reviewed

08/10/2023

Original Document

  Reference



This document addresses the use of gene expression profiling (GEP) as a laboratory test to assist in the identification of the tissue of origin for cancers of unknown primary (CUP).

This document does not address panel testing. Please refer to:

  • GENE.00052 Whole Genome Sequencing, Whole Exome Sequencing, Gene Panels, and Molecular Profiling

Position Statement

Investigational and Not Medically Necessary:

Gene expression profiling is considered investigational and not medically necessary as a technique to identify the tissue of origin for cancers of unknown primary site for all indications, including but not limited to:

  1. Determining the tissue of origin for a primary tumor; or
  2. Determining the tissue of origin for a metastatic tumor.