Anthem Blue Cross Connecticut LAB.00050 Metagenomic Sequencing for Infectious Disease in the Outpatient Setting Form

Effective Date


Last Reviewed


Original Document


This document addresses metagenomic sequencing of infectious pathogens in the outpatient setting. Metagenomic testing, which employs next generation sequencing (NGS), analyzes microbial DNA from a clinical sample without reliance on traditional culture or targeted molecular tests. Clinical metagenomic testing is used for comprehensive detection of all pathogens in a single test.

This document does not address targeted or multiplex (panel-based) nucleic acid tests (NAAT) or metagenomic sequencing of infectious diseases in the inpatient setting.

Position Statement

Investigational and Not Medically Necessary:

Metagenomic sequencing for infectious diseases in the outpatient setting is considered investigational and not medically necessary for all indications.

Want to learn more?