Lipoprotein, blood; high resolution fractionation and quantitation of lipoproteins including lipoprotein subclasses when performed (eg, electrophoresis, ultracentrifugation)
CPT4 code
Name of the Procedure:
Lipoprotein Blood Test; High Resolution Fractionation and Quantitation of Lipoproteins
Summary
A Lipoprotein Blood Test with high-resolution fractionation and quantitation involves analyzing lipoproteins, including their subclasses, to evaluate lipid levels more precisely. Techniques such as electrophoresis or ultracentrifugation separate and quantify these lipoproteins.
Purpose
This test helps in diagnosing and monitoring disorders related to abnormal lipid levels in the blood. It permits detailed assessment of different lipoprotein particles, aiding in the management of cardiovascular diseases.
Indications
- Elevated cholesterol or triglyceride levels
- Family history of cardiovascular diseases
- Unexplained occurrences of chest pain or stroke
- Conditions like metabolic syndrome, diabetes, or hypothyroidism that affect lipid metabolism
Preparation
- Fasting for 9-12 hours before the test to ensure accurate results
- Discuss current medications with the healthcare provider, as some might need adjustment
- Initial blood tests and health assessments to evaluate overall health status
Procedure Description
- A blood sample is drawn from a vein in your arm.
- The sample is processed using high-resolution techniques like electrophoresis or ultracentrifugation.
- Electrophoresis: Uses an electric field to separate lipoprotein particles based on size and charge.
- Ultracentrifugation: Utilizes high-speed spinning to separate particles based on density.
- Each subclass of lipoprotein is quantified and analyzed.
Duration
The blood draw process takes about 10-15 minutes. The separation and analysis process might take several hours to a few days, depending on the laboratory.
Setting
Performed in a hospital laboratory, outpatient clinic, or a specialized diagnostic center.
Personnel
- Phlebotomist or nurse to draw the blood sample
- Laboratory technicians for processing and analysis
- A pathologist or specialized healthcare provider to interpret the results
Risks and Complications
- Minor risks like bruising, bleeding, or infection at the blood draw site
- Rarely, fainting or dizziness from the blood draw
Benefits
- Precise assessment of lipid levels, including specific lipoprotein subclasses
- Better risk stratification for cardiovascular diseases
- Tailored treatment plans based on detailed lipoprotein profiles
Recovery
- Minimal to no recovery time needed
- Follow usual activities immediately after the blood draw
- Awaiting results may take a few days, during which normal activities can continue
Alternatives
- Standard lipid panel tests (less detailed)
- Benefits: More readily available, quicker, and less expensive
- Downsides: Less precise information on lipoprotein subclasses
Patient Experience
- Mild discomfort or a pinch during the blood draw
- Minimal aftereffects; a bandage may be applied to the site
- Instructions for any pain management will be provided if needed
Pain management and comfort measures: Application of a small pressure bandage post-draw; avoid heavy lifting or strenuous activities with the arm used for the draw for a short period.