Oncology (lung), mass spectrometric 8-protein signature, including amyloid A, utilizing serum, prognostic and predictive algorithm reported as good versus poor overall survival
CPT4 code
Name of the Procedure:
Oncology (lung), Mass Spectrometric 8-Protein Signature Test Including Amyloid A
Summary
This test analyzes a sample of serum (a component of blood) using mass spectrometry to measure the levels of eight specific proteins, including amyloid A. It helps doctors predict the overall survival rates for patients with lung cancer by categorizing them as having good or poor overall survival.
Purpose
The test is designed for patients diagnosed with lung cancer. It aims to provide a prognostic and predictive outlook regarding the patient's survival chances, which can guide treatment decisions and help manage the cancer more effectively.
Indications
- Diagnosed with lung cancer
- Need for tailored treatment plans based on prognosis
- When detailed protein level analysis can help in decision-making
Preparation
- No special preparation typically required
- Follow any specific instructions given by healthcare provider
Procedure Description
- Blood Draw: A sample of blood is collected from the patient.
- Serum Extraction: Serum is separated from the rest of the blood.
- Mass Spectrometry Analysis: The serum sample is analyzed using mass spectrometry to measure eight specific proteins, including amyloid A.
- Algorithm Application: The measured protein levels are input into a prognostic algorithm.
- Results Reporting: The algorithm classifies the survival prognosis as either good or poor.
Duration
Typically, the blood draw and mass spectrometry analysis can each take a few minutes, but the entire process, including reporting, may take a few days.
Setting
- Outpatient clinic
- Specialized laboratory for the mass spectrometry analysis
Personnel
- Phlebotomist or nurse to draw blood
- Laboratory technicians to perform the mass spectrometry analysis
- Oncologist to interpret results
Risks and Complications
- Minor discomfort or bruising from the blood draw
- Minimal risk of infection at blood draw site
Benefits
- Provides valuable information about the likely survival outcomes
- Helps in making informed decisions about treatment plans
- Early and better-managed care based on precise prognostic information
Recovery
- No special recovery period needed after blood draw
- Regular activities can be resumed immediately
Alternatives
- Traditional imaging and biopsy methods for lung cancer prognosis
- Genetic testing and other biomarker tests
- Pros: May provide additional or corroborative information
- Cons: May not be as precise as the mass spectrometric 8-protein signature
Patient Experience
During the procedure:
- Minor pain during the blood draw which is brief
After the procedure:
- No lasting discomfort
- Await results and consultation with the oncologist on further steps based on prognosis