SLCO1B1 (solute carrier organic anion transporter family, member 1B1) (eg, adverse drug reaction), gene analysis, common variant(s) (eg, *5)
CPT4 code
Name of the Procedure:
SLCO1B1 Gene Analysis (Solute Carrier Organic Anion Transporter Family, Member 1B1), Common Variant Assessment (e.g., *5)
Summary
SLCO1B1 gene analysis is a genetic test that checks for common variants in the SLCO1B1 gene. These variants can affect how certain drugs are processed by your body, potentially causing adverse drug reactions.
Purpose
Medical Condition: Adverse drug reactions (e.g., increased risk of muscle pain, liver toxicity) Goals: Identify genetic variants that impact drug metabolism, allowing for personalized medication plans to minimize adverse effects.
Indications
Symptoms/Conditions: Unexplained adverse reactions to specific drugs (e.g., statins), family history of drug sensitivity. Patient Criteria: Anyone experiencing unusual side effects from medications, those with a family history of adverse drug reactions, or patients about to begin long-term medication that has known SLCO1B1 interactions.
Preparation
Pre-Procedure Instructions: None typically required. Diagnostic Tests: Usually, a simple blood draw or saliva sample collection.
Procedure Description
- Sample Collection: A blood sample or saliva swab is taken from the patient.
- Lab Analysis: The sample is sent to a laboratory, where DNA is extracted and analyzed for common SLCO1B1 variants (e.g., *5).
- Results: Genetic results are reviewed and interpreted by a specialist to determine any impact on drug metabolism.
Tools and Equipment: Blood collection kit or saliva swab kit, DNA sequencing technology. Anesthesia/Sedation: Not applicable.
Duration
The sample collection takes about 5-10 minutes. Results typically take 1-2 weeks to process and analyze.
Setting
Sample collection can be performed in a doctor’s office, clinic, or laboratory.
Personnel
Healthcare Professionals: The procedure might involve medical technicians, nurses, and geneticists for sample analysis.
Risks and Complications
Common Risks: Minimal, slight discomfort at the blood draw site. Rare Risks: In very rare cases, there might be an infection or prolonged bleeding at the blood draw site.
Benefits
Expected Benefits: Identification of genetic variants helps in tailoring medication plans to prevent adverse drug reactions, improving overall treatment efficacy and safety. Timeline for Benefits: Benefits are realized when starting or adjusting medications based on genetic results.
Recovery
No significant recovery needed. Patients can resume normal activities immediately after sample collection.
Alternatives
Other Options: Full pharmacogenomic testing, trial and error with medication. Pros and Cons: Full pharmacogenomic testing provides a broader analysis but might be more expensive. Trial and error can help identify issues but may expose the patient to unnecessary side effects.
Patient Experience
During Procedure: Minimal discomfort during sample collection. After Procedure: Generally no pain; may have slight soreness if blood draw was performed. Stress relief knowing that their medication plan is optimized based on genetic information.